TFF System

GE Healthcare Uniflux 10

Condition Used
Stock Number 46915
This listing is for a GE Healthcare Uniflux 10 TFF System.


The unit is in full working condition and is ready for immediate release.


Supplied with x2 Watson Marlow 520BP Pumps


The GE Healthcare UniFlux 10 is part of a fully automated series of tangential flow filtration (TFF) systems designed to facilitate clarification, concentration, and diafiltration across pilot to manufacturing scales.


Overview:Fully Automated TFF/Cross Flow System: The UniFlux 10 is engineered for complete automation in tangential flow filtration, maximizing productivity and ensuring consistent, repeatable, and validatable results throughout the filtration process.

Adjustable Flow Rate: The UniFlux 10 offers a flow rate range of 0.5 to 10 liters per minute, allowing flexibility to adapt to different sample volumes and process requirements while maintaining efficient filtration.

Recirculation and Mixing Options: The system supports recirculation tanks ranging from 5 to 600 liters for efficient fluid management or can utilize single-use mixing systems as alternatives to traditional stainless steel tanks, simplifying setup and cleanup.


Key Features:UNICORN Control Software: The UniFlux 10 utilizes UNICORN software for full automation, which includes comprehensive data logging capabilities throughout the entire cross flow process. This system is designed to comply with FDA regulations, particularly 21 CFR Part 11, making it suitable for use in regulated environments.

Familiar User Interface: Users familiar with GE Healthcare’s chromatography systems, such as the bench-top ÄKTA systems and production-scale ÄKTAprocess, will find the UniFlux interface intuitive, facilitating a smoother transition for operators.

Versatility in Filtration: The UniFlux system is suitable for microfiltration (MF) and ultrafiltration (UF) applications, incorporating high-performance cross flow filters like hollow fiber cartridges and filter cassettes tailored for diverse bioprocessing needs.

Flow Rate Flexibility: Specifically, the UniFlux 10 features a flow rate range from 0.5 to 10 liters per minute, allowing for effective filtration tailored to varying sample sizes and process demands.

Diaphragm Pump Technology: The use of a diaphragm pump ensures stable and consistent flow rates, essential for achieving optimal filtration performance.

Optional Triple Inlet Valve: An optional triple inlet valve allows for the seamless introduction of multiple fluids—products, buffers, and cleaning solutions—without the need for switching tubing, enhancing operational efficiency.


Applications:Biopharmaceutical Production: It is essential for the clarification and concentration of biological products, including monoclonal antibodies, vaccines, and other critical biopharmaceuticals, ensuring high yield and purity.

Cell Culture Processing: Streamlines the filtration of complex cell cultures, enabling effective recovery of valuable biomolecules while removing unwanted debris and contaminants.

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Buffer Exchange and Diafiltration: Facilitates effective buffer exchange processes, essential for preparing products for downstream processing and formulation.